Antimony trioxide is a respiratory carcinogen in female rats. 888-232-6348 (TTY) Note: Javascript is disabled or is not supported by your browser. Cancer; Listed as causing: Cancer. For this reason, some items on this page will be unavailable. It is insoluble in water. The .gov means it's official. Antimony(III) oxide is the inorganic compound with the formula Sb 2 O 3.It is the most important commercial compound of antimony.It is found in nature as the minerals valentinite and senarmontite. The site is secure. It can be harmful to the eyes and skin. Basis for Listing AB-IARC. The International Agency for Research on Cancer has determined that antimony trioxide is possibly carcinogenic to humans and that antimony trisulfide is not classifiable. recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. The US National Toxicology Program (NTP) recently recommended in its Report on Carcinogens Monograph for Antimony Trioxide that antimony trioxide be These archived materials frequently include presentations, background materials, and public comments. Date of Listing: 10/01/1990. NIEHS has helpful information on accessibility. Rat oral LD 50 >34 g kg −1. What is antimony trioxide? *Antimony Trioxidemay be a CARCINOGEN in humans since it has been shown to cause lung cancer in animals. Arsenic trioxide may also be used for other purposes not listed in this medication guide. Evidence for lung neoplasms caused by antimony trioxide inhalation in e … Before sharing sensitive information, make sure you're on a federal government site. Caroline Braibant - Human Health: Genotoxicity, Caroline Braibant - Human Health: Lung Toxicity and Carcinogenicity, Testing Status of Antimony Trioxide 10676-V, National Institute of Environmental Health Sciences, Federal Register notice requesting public comment on nominated substances (, Division of Medical Toxicology at Drexel University College of Medicine. : A860-100; A860-500 CAS-No 1309-64-4 Synonyms Antimony trioxide Recommended Use Laboratory chemicals. The primary hazard is the threat to the environment. Inhalation (Particles) The average room-air concentration and average exposure concentration for antimony trioxide were obtained as described for the noncancer risk assessment of particles. Antimony Oxide (Antimony trioxide) Antimony Oxide (Antimony trioxide) Listed as Causing Cancer. Groth DH, Stettler LE, Burg JR, Busey WM, Grant GC, Wong L. This study was initiated because of a suspected increase in incidence of lung cancer in antimony smelter workers in England. Workers may be harmed from exposure to antimony and its compounds. ANTIMONY TRIOXIDE 256 Cancer There are inadequate data to assess the carcinogenicity of antimony trioxide from dermal or oral exposures. One compound — antimony trioxide — is even believed to be carcinogenic, and antimony poisoning has also been known to lead to Adams-Stokes syndrome. This list contains substances to which pregnant workers and workers who have recently given birth or are breastfeeding may not be exposed. Cancer: 10/01/1990. In addition, the available mechanistic and other relevant data (such as disposition and toxicokinetics) are assessed, and the final listing recommendation is based on an integration of all the relevant information (as summarized in the table above). Fact Sheets; The level of exposure depends upon the dose, duration, and work being done. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Breathing air contaminated with antimony can cause eye and lung irritation, heart and lung damage, stomach pains, diarrhea, vomiting, and stomach ulcers. Chemical Status; Cancer: Currently listed. Mouse intraperitoneal LD 50 =172 mg kg −1. Typical and worst-case inhalation scenarios in multiple occupational settings were used in risk estimation. However, there are companies in the United States that produce antimony … Supplemental materials for events, meetings, and workshops prior to 2017 have been archived. The HEEP for Antimony Oxides (U.S. EPA, 1985) and HEA for Antimony and Compounds (U.S. EPA, 1987) acknowledged there was suggestive evidence Antimony trioxide is a white crystalline solid. Chemical Listing Details. Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL. The in vivo genotoxicity of antimony trioxide was studied using single and repeat dose mouse bone marrow micronucleus tests, and the rat liver unscheduled DNA synthesis assay. It has also been listed as a possible human carcinogen by the International Agency for Research on Cancer. Antimony potassium tartrate has been used worldwide as an anti-shistosomal drug. Agency for Toxic Substances and Disease Registry. Arsenic trioxide is sometimes given in combination with another medicine called tretinoin. Antimony is toxic and several states have identified it as a safety concern for children’s products. For assistance, email us or use our contact form and identify the documents/pages for which access is required. Status: Cancer hazard evaluation for potential listing in the Report on Carcinogens (RoC) Primary Uses or Exposures Oxide of trivalent (+3) antimony and … Exposure to antimony trioxide may increase the risk of cancer. Antimony Oxide (Antimony trioxide) Antimony Oxide (Antimony trioxide) More information about Antimony Trioxide. Reports on Peer Reviews for the Report on Carcinogens. Federal government websites often end in .gov or .mil. What happens when I eat or breathe antimony? Antimony carcinogenicity evidence involving workers is inadequate, based on confounding, small sample sizes, incomparability across studies, and inadequate reference populations. How can I protect myself and my family from antimony? Results: In typical case scenarios, the occupational cancer risk from antimony trioxide was estimated to be 0.025 (25 in 1000) for persons working with flame retardants in plastics and textiles for 40 years. Oxide of trivalent (+3) antimony and most commercially significant form of antimony. Proposition 65 requires businesses to determine if they must provide a warning about significant exposure to listed chemicals. We will assist you in accessing the content of these files. Antimony sesquioxide; Antimonous oxide; Antimony oxide, Oxo-oxostibanyloxystibane; Diantimony trioxide . A cancer assessment for antimony trioxide is not available on IRIS (U.S. EPA, 2008) or in the HEAST (U.S. EPA, 1997). An official website of the United States government. These clinics specialize in Human studies are inconclusive regarding antimony exposure and cancer, while animal studies have reported lung tumors in rats exposed to antimony trioxide via inhalation. EPA has not classified antimony for carcinogenicity. Results In typical case scenarios, the occupational cancer risk from antimony trioxide was estimated to be 0.025 (25 in 1000) for persons working with flame retardants in … Take off all contaminated clothing. They can potentially be exposed when using consumer products containing antimony trioxide or breathing contaminated air. The Department of Health and Human Services (HHS) considers antimony trioxide to be reasonably anticipated to be a human carcinogen (causing cancer in people). Email: Contact CDC-INFO. Antimony trioxide was last classified by the International Agency for Research on Cancer (IARC) in 1989 as Group 2B, possibly carcinogenic to humans, based on inadequate evidence in humans and sufficient evidence in animals. level of evidence from cancer studies of antimony(III) trioxide in humans and experimental animals. Ahmed Mostafa, M.D., Ryan Surmaitis, D.O., Maricel Dela Cruz, D.O., Michael Greenberg, M.D., Muhammad Khalid, M.D. Primarily used as a synergist for halogenated flame retardants in plastics, rubber, and textiles, all of which are used in a wide variety of consumer products. Products containing antimony trioxide may also be used for the treatment of leishmaniasis requires businesses to if... The documents/pages for which access is required 65 list because it can be harmful to State. 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